Trithiolato-bridged dinuclear ruthenium(II)-arene conjugates tethered with lipophilic units: Synthesis and Toxoplasma gondii antiparasitic activity

Synthesis of the cyanobacterial metabolite nostodione A, structural studies and potent antiparasitic activity against Toxoplasma gondii.

A total synthesis of the cyanobacterial natural product nostodione A is reported involving a convergent, diversity-oriented route, enabling the assembly of a mini-library of structural analogues. The first single crystal X-ray structural determination on a member of this series is reported along with SAR studies identifying potent inhibitors of invasion and replication of the parasitic protozoa...

Total synthesis of the cyanobacterial metabolite nostodione A: discovery of its antiparasitic activity against Toxoplasma gondii.

A total synthesis of the cyanobacterial natural product nostodione A is reported involving a convergent, diversity-oriented route. A small assemblage of structural analogues were prepared and their cytotoxicity and anti-invasion activity against the protozoal parasite Toxoplasma gondii is reported for the first time.

Antiparasitic effects of Zingiber officinale (Ginger) extract against Toxoplasma gondii

Synthesis, Spectroscopy and Magnetism of Alkoxobridged Dinuclear Copper(II) Complexes with 2  Amino  Picolines as the Ligands

The synthesis, spectroscopic and magnetic characterization of a series of new alkoxo-bridged binuclear copper (II) compounds are described. All complexes have the general formula [Cu (m-OR)(L)2]2(ClO4)2 · x H2O, in which m-OR = CH3O-, C2H5O- or C3H7O-<e...

RutheniumII(η6-arene) complexes of thiourea derivatives: synthesis, characterization and urease inhibition.

RuII(arene) complexes have emerged as a versatile class of compounds to design metallodrugs as potential treatment for a wide range of diseases including cancer and malaria. They feature modes of action that involve classic DNA binding like platinum anticancer drugs, may covalent binding to proteins, or multimodal biological activity. Herein, we report the synthesis and urease inhibition activi...